Sunday, December 5, 2010


Ubiquitination: labelling the proteins

In the late 70’s and early 80’s, ground-breaking research led to the discovery of a highly-specific, energy-dependent process enabling the cell to target specific proteins for degradation. In 2004, Aaron Ciechanover, Avram Hershko and Irwin Rose were awarded the Nobel Prize in Chemistry for their discovery, which enabled the understanding of protein degradation at the molecular level as well as its implication in biological processes as diverse as control of the cell cycle, gene transcription and immunity (1, 2


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